reviewTheranosticsJan 1, 2023GOLD OA

Organ-on-a-chip meets artificial intelligence in drug evaluation

Chinese Academy of Medical Sciences & Peking Union Medical College · China Academy of Chinese Medical Sciences · +1 more institution

PubMed
Indexed incrossrefdoajpubmed

Abstract

Drug evaluation has always been an important area of research in the pharmaceutical industry. However, animal welfare protection and other shortcomings of traditional drug development models pose obstacles and challenges to drug evaluation. Organ-on-a-chip (OoC) technology, which simulates human organs on a chip of the physiological environment and functionality, and with high fidelity reproduction organ-level of physiology or pathophysiology, exhibits great promise for innovating the drug development pipeline. Meanwhile, the advancement in artificial intelligence (AI) provides more improvements for the design and data processing of OoCs. Here, we review the current progress that has been made to generate OoC…

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