Gut microbial carbohydrate metabolism contributes to insulin resistance

Abstract Insulin resistance is the primary pathophysiology underlying metabolic syndrome and type 2 diabetes 1,2 . Previous metagenomic studies have described the characteristics of gut microbiota and their roles in metabolizing major nutrients in insulin resistance 3–9 . In particular, carbohydrate metabolism of commensals has been proposed to contribute up to 10% of the host’s overall energy extraction 10 , thereby playing a role in the pathogenesis of obesity and prediabetes 3,4,6 . Nevertheless, the underlying mechanism remains unclear. Here we investigate this relationship using a comprehensive multi-omics strategy in humans. We combine unbiased faecal metabolomics with metagenomics, host metabolomics and…

• JA
  Japan Agency for Medical Research and Development

  Awards: CREST, JP22zf0127007, 19gm0710009h0006
• WT
  Wellcome Trust
• KI
  Kanagawa Institute of Industrial Science and Technology
• NI
  National Institute for Health and Care Research
• KC
  King's College London
• EC
  European Commission
• OM
  Ono Medical Research Foundation
• VA
  Versus Arthritis
• MR
  Medical Research Council
• JS
  Japan Society for the Promotion of Science

  Awards: JP22zf0127007, 19K08991, 22H00452, CREST, 21K18216, 15H05897
• R
  RIKEN
• CR
  Core Research for Evolutional Science and Technology
• ER
  Exploratory Research for Advanced Technology

  Award: JPMJER2101
• MR
  Moonshot Research and Development Program

  Award: JP22zf0127007