reviewExperimental & Molecular MedicineSep 1, 2023GOLD OA

Functional significance of cholesterol metabolism in cancer: from threat to treatment

MXMingming XiaoJXJin XuWWWei WangBZBo ZhangJLJiang Liu

Shanghai Medical College of Fudan University · Fudan University · +1 more institution

PubMed
Indexed incrossrefdoajpubmed

Abstract

Cholesterol is an essential structural component of membranes that contributes to membrane integrity and fluidity. Cholesterol homeostasis plays a critical role in the maintenance of cellular activities. Recently, increasing evidence has indicated that cholesterol is a major determinant by modulating cell signaling events governing the hallmarks of cancer. Numerous studies have shown the functional significance of cholesterol metabolism in tumorigenesis, cancer progression and metastasis through its regulatory effects on the immune response, ferroptosis, autophagy, cell stemness, and the DNA damage response. Here, we summarize recent literature describing cholesterol metabolism in cancer cells, including the…

Citation impact

194
total citations
FWCI
44.73
Percentile
100%
References
164
Citations per year

Authors

10

Topics & keywords

Topics
Keywords
  • Cancer
  • Cholesterol
  • Autophagy
  • Carcinogenesis
  • Biology
  • Cancer cell
  • Immune system
  • Metastasis
UN Sustainable Development Goals
  • Good health and well-being
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