Integration of AIEgens into covalent organic frameworks for pyroptosis and ferroptosis primed cancer immunotherapy

Immunogenic programmed cell death, such as pyroptosis and ferroptosis, efficiently induces an acute inflammatory response and boosts antitumor immunity. However, the exploration of dual-inducers, particularly nonmetallic inducers, capable of triggering both pyroptosis and ferroptosis remains limited. Here we show the construction of a covalent organic framework (COF-919) from planar and twisted AIEgen-based motifs as a dual-inducer of pyroptosis and ferroptosis for efficient antitumor immunity. Mechanistic studies reveal that COF-919 displays stronger near-infrared light absorption, lower band energy, and longer lifetime to favor the generation of reactive oxygen species (ROS) and photothermal conversion,…

• NN
  National Natural Science Foundation of China

  Awards: 82002879, 2042017kf0232, 21788102, 21971199, 22025106, 82273202, 91545205, 2022YFC2504200, 82072996, 91622103
• CA
  Chinese Academy of Sciences
• CP
  China Postdoctoral Science Foundation

  Awards: 2021T140524, 2021M692475, XJ2021037, 21788102
• IA
  Innovation and Technology Commission

  Award: ITCCNERC14SC01
• HK
  Hong Kong University of Science and Technology
• WU
  Wuhan University

  Awards: 2042017kf0232, 91545205, XNJC202303
• NK
  National Key Research and Development Program of China

  Awards: 2018YFA0704000, 2022YFC2504200, 91545205, 2042017kf0232, 2014CB239203, 21788102