reviewCell Death and DiseaseSep 4, 2023GOLD OA

Stromal cells in the tumor microenvironment: accomplices of tumor progression?

YZYan ZhaoMSMeili ShenLWLiangqiang WuHYHaiqin YangYYYixuan Yao

Jilin University · Union Hospital

PubMed
Indexed incrossrefdoajpubmed

Abstract

The tumor microenvironment (TME) is made up of cells and extracellular matrix (non-cellular component), and cellular components include cancer cells and non-malignant cells such as immune cells and stromal cells. These three types of cells establish complex signals in the body and further influence tumor genesis, development, metastasis and participate in resistance to anti-tumor therapy. It has attracted scholars to study immune cells in TME due to the significant efficacy of immune checkpoint inhibitors (ICI) and chimeric antigen receptor T (CAR-T) in solid tumors and hematologic tumors. After more than 10 years of efforts, the role of immune cells in TME and the strategy of treating tumors based on immune…

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387
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84.21
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100%
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313
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Authors

10

Topics & keywords

Topics
Keywords
  • Stromal cell
  • Tumor microenvironment
  • Immune system
  • Cancer research
  • Metastasis
  • Biology
  • Transdifferentiation
  • Angiogenesis
UN Sustainable Development Goals
  • Good health and well-being
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