Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials
University of British Columbia · Canada's Michael Smith Genome Sciences Centre · +3 more institutions
Abstract
Undruggable proteins are a class of proteins that are often characterized by large, complex structures or functions that are difficult to interfere with using conventional drug design strategies. Targeting such undruggable targets has been considered also a great opportunity for treatment of human diseases and has attracted substantial efforts in the field of medicine. Therefore, in this review, we focus on the recent development of drug discovery targeting "undruggable" proteins and their application in clinic. To make this review well organized, we discuss the design strategies targeting the undruggable proteins, including covalent regulation, allosteric inhibition, protein-protein/DNA interaction…
Citation impact
- FWCI
- 48.53
- Percentile
- 100%
- References
- 675
Authors
8- XXXin XieCorresponding
University of British Columbia, Canada's Michael Smith Genome Sciences Centre, Chengdu University of Traditional Chinese Medicine
- TYTingting Yu
Chengdu University of Traditional Chinese Medicine
- XLXiang Li
Chengdu University of Traditional Chinese Medicine
- NZNan Zhang
Sichuan University, State Key Laboratory of Biotherapy, Chengdu University of Traditional Chinese Medicine
- LJLeonard J. Foster
University of British Columbia, Canada's Michael Smith Genome Sciences Centre
Topics & keywords
- Drug discovery
- Computational biology
- Drug development
- Biology
- Drug
- Bioinformatics
- Pharmacology
- Good health and well-being