Spatial predictors of immunotherapy response in triple-negative breast cancer

Wang, Xiao Qian; Danenberg, Esther; Huang, Chiun‐Sheng; Egle, Daniel; Callari, Maurizio; Bermejo, Begoña; Dugo, Matteo; Zamagni, Claudio; Thill, Marc; Anton, Anton; Zambelli, Stefania; Russo, Stefania; Ciruelos, Eva; Greil, Richard; Győrffy, Balázs; Semiglazov, Vladimir; Colleoni, Marco; Kelly, Catherine M.; Mariani, Gabriella; Mastro, Lucia Del; Biasi, Olivia; Seitz, Robert S.; Valagussa, Pinuccia; Viale, Giuseppe; Gianni, Luca; Bianchini, Giampaolo; Ali, H. Raza

doi:10.1038/s41586-023-06498-3

articleNatureSep 6, 2023HYBRID OA

Spatial predictors of immunotherapy response in triple-negative breast cancer

XQXiao Qian Wang EDEsther Danenberg CHChiun‐Sheng Huang DEDaniel Egle MCMaurizio Callari

University of Cambridge · National Taiwan University Hospital · +26 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Abstract Immune checkpoint blockade (ICB) benefits some patients with triple-negative breast cancer, but what distinguishes responders from non-responders is unclear 1 . Because ICB targets cell–cell interactions 2 , we investigated the impact of multicellular spatial organization on response, and explored how ICB remodels the tumour microenvironment. We show that cell phenotype, activation state and spatial location are intimately linked, influence ICB effect and differ in sensitive versus resistant tumours early on-treatment. We used imaging mass cytometry 3 to profile the in situ expression of 43 proteins in tumours from patients in a randomized trial of neoadjuvant ICB, sampled at three timepoints…

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309

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Topics & keywords

Topics

Keywords

Immune checkpoint
Breast cancer
CD8
Cancer research
Immune system
Triple-negative breast cancer
Immunotherapy
Tumor microenvironment

UN Sustainable Development Goals

Good health and well-being

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