Circular RNA vaccine in disease prevention and treatment

CircRNAs are a class of single-stranded RNAs with covalently linked head-to-tail topology. In the decades since its initial discovery, their biogenesis, regulation, and function have rapidly disclosed, permitting a better understanding and adoption of them as new tools for medical applications. With the development of biotechnology and molecular medicine, artificial circRNAs have been engineered as a novel class of vaccines for disease treatment and prevention. Unlike the linear mRNA vaccine which applications were limited by its instability, inefficiency, and innate immunogenicity, circRNA vaccine which incorporate internal ribosome entry sites (IRESs) and open reading frame (ORF) provides an improved…

• NN
  National Natural Science Foundation of China

  Award: 82073300
• NS
  Natural Science Foundation of Chongqing

  Awards: CSTB2022NSCQ-LZX0018, 2022NSCQ-LZX0116, CSTB2022NSCQ
• CS
  Centre Scientifique et Technique du Bâtiment