Transcriptional and epigenetic decoding of the microglial aging process
Fudan University · Zhongshan Hospital · +8 more institutions
Abstract
As important immune cells, microglia undergo a series of alterations during aging that increase the susceptibility to brain dysfunctions. However, the longitudinal characteristics of microglia remain poorly understood. In this study, we mapped the transcriptional and epigenetic profiles of microglia from 3- to 24-month-old mice. We first discovered unexpected sex differences and identified age-dependent microglia (ADEM) genes during the aging process. We then compared the features of aging and reactivity in female microglia at single-cell resolution and epigenetic level. To dissect functions of aged microglia excluding the influence from other aged brain cells, we established an accelerated microglial turnover…
Citation impact
- FWCI
- 20.39
- Percentile
- 100%
- References
- 159
Authors
22Topics & keywords
- Microglia
- Epigenetics
- Neuroscience
- Biology
- Ageing
- Cognitive decline
- Senescence
- Gene
Funding
- NNNational Natural Science Foundation of ChinaAwards: 82171082, 32170958, 32000678
- MOMinistry of Science and Technology of the People's Republic of ChinaAwards: STI2030-Major Projects (2022ZD0207200), STI2030-Major Projects (2022ZD0204700)
- SAScience and Technology Commission of Shanghai MunicipalityAward: Program of Shanghai Academic/Technology Research Leader (21XD1420400)
- STScience, Technology and Innovation Commission of Shenzhen MunicipalityAwards: JCYJ20210324101603009, Shenzhen Science and Technology Research Program (JCYJ20180507182033219)