articleAnalytical ChemistrySep 14, 2023Closed access

Block-Polymer-Restricted Sub-nanometer Pt Nanoclusters Nanozyme-Enhanced Immunoassay for Monitoring of Cardiac Troponin I

SCShuyun ChenZYZhichao YuYWYunsen WangJTJuan TangYZYongyi Zeng

Fuzhou University · Jiangxi Normal University · +2 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Noble-metal nanozymes have demonstrated great potential in various fields. However, aggregation of single-particle nanoparticles severely affects their exposed catalytically active sites to the extent of exhibiting weak enzyme-like activity. Here, we present an organic block surfactant (polyvinylpyrrolidone, PVP) to construct monodisperse water-stable Pt nanoclusters (Pt NCs) for an enhanced immunoassay of cardiac troponin I (cTnI). The PVP-modified Pt NC nanozyme exhibited up to 16.3 U mg–1 peroxidase-mimicking activity, which was mainly attributed to the ligand modification on the surface and the electron-absorbing effect of the ligand on the Pt NCs. The PVP-modified Pt NCs have a lower OH-transition…

Citation impact

179
total citations
FWCI
16.19
Percentile
100%
References
57
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Authors

7

Topics & keywords

Topics
Keywords
  • Chemistry
  • Nanoclusters
  • Immunoassay
  • Detection limit
  • Polyvinylpyrrolidone
  • Ligand (biochemistry)
  • Dispersity
  • Nanoparticle
UN Sustainable Development Goals
  • Clean water and sanitation
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