Endoplasmic reticulum stress: molecular mechanism and therapeutic targets
Central South University · Xiangya Hospital Central South University · +1 more institution
Abstract
The endoplasmic reticulum (ER) functions as a quality-control organelle for protein homeostasis, or "proteostasis". The protein quality control systems involve ER-associated degradation, protein chaperons, and autophagy. ER stress is activated when proteostasis is broken with an accumulation of misfolded and unfolded proteins in the ER. ER stress activates an adaptive unfolded protein response to restore proteostasis by initiating protein kinase R-like ER kinase, activating transcription factor 6, and inositol requiring enzyme 1. ER stress is multifaceted, and acts on aspects at the epigenetic level, including transcription and protein processing. Accumulated data indicates its key role in protein homeostasis…
Citation impact
- FWCI
- 175.82
- Percentile
- 100%
- References
- 514
Authors
5- XCXingyi ChenCorresponding
Central South University, Xiangya Hospital Central South University
- CSChaoran Shi
Central South University, Xiangya Hospital Central South University
- MHMeihui He
Central South University, Xiangya Hospital Central South University
- SXSiqi Xiong
Central South University, National Clinical Research, Xiangya Hospital Central South University
- XXXiaobo Xia
Central South University, National Clinical Research, Xiangya Hospital Central South University
Topics & keywords
- Proteostasis
- Unfolded protein response
- Endoplasmic reticulum
- TFEB
- Cell biology
- Biology
- Retinitis pigmentosa
- Protein kinase A
- Good health and well-being