TTD: Therapeutic Target Database describing target druggability information

Target discovery is one of the essential steps in modern drug development, and the identification of promising targets is fundamental for developing first-in-class drug. A variety of methods have emerged for target assessment based on druggability analysis, which refers to the likelihood of a target being effectively modulated by drug-like agents. In the therapeutic target database (TTD), nine categories of established druggability characteristics were thus collected for 426 successful, 1014 clinical trial, 212 preclinical/patented, and 1479 literature-reported targets via systematic review. These characteristic categories were classified into three distinct perspectives: molecular interaction/regulation,…

• NN
  National Natural Science Foundation of China

  Awards: 81971982, 81872798, 2020C03010, 82373790, 215-432094250, 22220102001, U1909208
• NU
  Ningbo University

  Awards: 215-432094250, 215-432000282
• ZU
  Zhejiang University

  Award: 2020C03010
• NK
  National Key Research and Development Program of China

  Award: 2022YFC3400501
• NS
  Natural Science Foundation of Zhejiang Province

  Award: LR21H300001