GelMA-based bioactive hydrogel scaffolds with multiple bone defect repair functions: therapeutic strategies and recent advances
Central South University · Xiangya Hospital Central South University
Abstract
Currently, the clinical treatment of critical bone defects attributed to various causes remains a great challenge, and repairing these defects with synthetic bone substitutes is the most common strategy. In general, tissue engineering materials that mimic the structural, mechanical and biological properties of natural bone have been extensively applied to fill bone defects and promote in situ bone regeneration. Hydrogels with extracellular matrix (ECM)-like properties are common tissue engineering materials, among which methacrylate-based gelatin (GelMA) hydrogels are widely used because of their tunable mechanical properties, excellent photocrosslinking capability and good biocompatibility. Owing to their…
Citation impact
- FWCI
- 20.90
- Percentile
- 100%
- References
- 149
Authors
7- BZBixia ZhouCorresponding
Central South University, Xiangya Hospital Central South University
- XJXulei Jiang
Central South University, Xiangya Hospital Central South University
- XZXinxin Zhou
Central South University, Xiangya Hospital Central South University
- WTWuyuan Tan
Central South University, Xiangya Hospital Central South University
- HLHang Luo
Central South University
Topics & keywords
- Self-healing hydrogels
- Biocompatibility
- Materials science
- Biomedical engineering
- Tissue engineering
- Gelatin
- Bone healing
- Regeneration (biology)
Funding
- NNNational Natural Science Foundation of ChinaAwards: 82272293, 81974297, 81802136
- CSCentral South University
- NSNatural Science Foundation of Hunan ProvinceAwards: 2020JJ5939, 2023JJ30962, 2020JJ4907
- PRPostdoctoral Research Foundation of ChinaAward: 2018M643005
- XHXiangya Hospital, Central South UniversityAward: 2017Q18