Role of dopamine in the pathophysiology of Parkinson’s disease
Duke-NUS Medical School · National Neuroscience Institute · +5 more institutions
Abstract
A pathological feature of Parkinson's disease (PD) is the progressive loss of dopaminergic neurons and decreased dopamine (DA) content in the substantia nigra pars compacta in PD brains. DA is the neurotransmitter of dopaminergic neurons. Accumulating evidence suggests that DA interacts with environmental and genetic factors to contribute to PD pathophysiology. Disturbances of DA synthesis, storage, transportation and metabolism have been shown to promote neurodegeneration of dopaminergic neurons in various PD models. DA is unstable and can undergo oxidation and metabolism to produce multiple reactive and toxic by-products, including reactive oxygen species, DA quinones, and 3,4-dihydroxyphenylacetaldehyde.…
Citation impact
- FWCI
- 47.95
- Percentile
- 100%
- References
- 165
Authors
5- ZZZhidong ZhouCorresponding
Duke-NUS Medical School, National Neuroscience Institute
- LYLing Yi
National Neuroscience Institute
- DQDennis Qing Wang
Zhujiang Hospital, Southern Medical University
- TMTit Meng Lim
National University of Singapore
- EKEng King TanCorresponding
Singapore General Hospital, National Neuroscience Institute, Signature Research (United States)
Topics & keywords
- Parkinson's disease
- Neurology
- Neuroscience
- Dopamine
- Disease
- Pathophysiology
- Medicine
- Psychology