Multifunctional PtCuTe Nanosheets with Strong ROS Scavenging and ROS‐Independent Antibacterial Properties Promote Diabetic Wound Healing

Nanozymes, as one of the most efficient reactive oxygen species (ROS)-scavenging biomaterials, are receiving wide attention in promoting diabetic wound healing. Despite recent attempts at improving the catalytic efficiency of Pt-based nanozymes (e.g., PtCu, one of the best systems), they still display quite limited ROS scavenging capacity and ROS-dependent antibacterial effects on bacteria or immunocytes, which leads to uncontrolled and poor diabetic wound healing. Hence, a new class of multifunctional PtCuTe nanosheets with excellent catalytic, ROS-independent antibacterial, proangiogenic, anti-inflammatory, and immuno-modulatory properties for boosting the diabetic wound healing, is reported. The PtCuTe…

• NN
  National Natural Science Foundation of China

  Awards: 82221003, 22105007, 81991505, 82201123, U22A20160
• CP
  China Postdoctoral Science Foundation

  Awards: 2020M670018, 2023T160029, 2021M700279
• NS
  Natural Science Foundation of Beijing Municipality

  Award: 30307472319
• NK
  National Key Research and Development Program of China

  Award: 2021YFC2400404