reviewSignal Transduction and Targeted TherapySep 20, 2023GOLD OA

mRNA vaccines in disease prevention and treatment

Zhejiang Medicine (China) · First Affiliated Hospital Zhejiang University · +2 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

MRNA vaccines have emerged as highly effective strategies in the prophylaxis and treatment of diseases, thanks largely although not totally to their extraordinary performance in recent years against the worldwide plague COVID-19. The huge superiority of mRNA vaccines regarding their efficacy, safety, and large-scale manufacture encourages pharmaceutical industries and biotechnology companies to expand their application to a diverse array of diseases, despite the nonnegligible problems in design, fabrication, and mode of administration. This review delves into the technical underpinnings of mRNA vaccines, covering mRNA design, synthesis, delivery, and adjuvant technologies. Moreover, this review presents a…

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