Cingulate dynamics track depression recovery with deep brain stimulation

Abstract Deep brain stimulation (DBS) of the subcallosal cingulate (SCC) can provide long-term symptom relief for treatment-resistant depression (TRD) 1 . However, achieving stable recovery is unpredictable 2 , typically requiring trial-and-error stimulation adjustments due to individual recovery trajectories and subjective symptom reporting 3 . We currently lack objective brain-based biomarkers to guide clinical decisions by distinguishing natural transient mood fluctuations from situations requiring intervention. To address this gap, we used a new device enabling electrophysiology recording to deliver SCC DBS to ten TRD participants (ClinicalTrials.gov identifier NCT01984710). At the study endpoint of 24…

• NS
  National Science Foundation

  Awards: 1350954, CAREER
• JS
  James S. McDonnell Foundation

  Award: 220020399
• HF
  Hope for Depression Research Foundation
• GI
  Georgia Institute of Technology
• UO
  University of Georgia
• UO
  University of Oxford
• NI
  National Institutes of Health

  Award: UH3NS103550
• NI
  National Institute of Neurological Disorders and Stroke

  Award: UH3NS103550