Dynamic light scattering and transmission electron microscopy in drug delivery: a roadmap for correct characterization of nanoparticles and interpretation of results
Åbo Akademi University · University of Reading · +5 more institutions
Abstract
In this focus article, we provide a scrutinizing analysis of transmission electron microscopy (TEM) and dynamic light scattering (DLS) as the two common methods to study the sizes of nanoparticles with focus on the application in pharmaceutics and drug delivery. Control over the size and shape of nanoparticles is one of the key factors for many biomedical systems. Particle size will substantially affect their permeation through biological membranes. For example, an enhanced permeation and retention effect requires a very narrow range of sizes of nanoparticles (50-200 nm) and even a minor deviation from these values will substantially affect the delivery of drug nanocarriers to the tumour. However, amazingly a…
Citation impact
- FWCI
- 41.98
- Percentile
- 100%
- References
- 84
Authors
7Topics & keywords
- Dynamic light scattering
- Pharmaceutics
- Characterization (materials science)
- Transmission electron microscopy
- Drug delivery
- Materials science
- Nanotechnology
- Nanoparticle
- Good health and well-being