Microenvironment-Responsive Metal-Phenolic Nanozyme Release Platform with Antibacterial, ROS Scavenging, and Osteogenesis for Periodontitis
Nanchang University · Jinggangshan University
Abstract
Periodontitis is a chronic inflammatory disease deriving from dental plaque, characterized by the excessive accumulation of reactive oxygen species (ROS), matrix metalloproteinase (MMP) and other substances, resulting in the destruction of periodontal tissues. At present, the main therapeutic modalities, such as local mechanical debridement and antibiotic delivery, are not only difficult to solve the intractable bacterial biofilm effectively but also tricky to ameliorate the excessive inflammatory response as well as regenerate the impaired periodontal tissues. Herein, we have proposed the TM/BHT/CuTA hydrogel system formed by the self-assembly of the copper-based nanozyme (copper tannic acid coordination…
Citation impact
- FWCI
- 30.30
- Percentile
- 100%
- References
- 54
Authors
12Topics & keywords
- Reactive oxygen species
- Periodontitis
- Chemistry
- Self-healing hydrogels
- Matrix metalloproteinase
- Superoxide dismutase
- Inflammation
- Reactive nitrogen species