articleCellSep 27, 2023HYBRID OA

The local microenvironment drives activation of neutrophils in human brain tumors

RRRoeltje R. MaasKSKlara SoukupNFNadine FournierMMMatteo MassaraSGSabine Galland

University Hospital of Lausanne · Ludwig Cancer Research · +7 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Neutrophils are abundant immune cells in the circulation and frequently infiltrate tumors in substantial numbers. However, their precise functions in different cancer types remain incompletely understood, including in the brain microenvironment. We therefore investigated neutrophils in tumor tissue of glioma and brain metastasis patients, with matched peripheral blood, and herein describe the first in-depth analysis of neutrophil phenotypes and functions in these tissues. Orthogonal profiling strategies in humans and mice revealed that brain tumor-associated neutrophils (TANs) differ significantly from blood neutrophils and have a prolonged lifespan and immune-suppressive and pro-angiogenic capacity. TANs…

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Topics & keywords

Topics
Keywords
  • Biology
  • Immune system
  • Tumor microenvironment
  • Myeloid
  • Tumor necrosis factor alpha
  • Immunology
  • Glioma
  • Inflammation
UN Sustainable Development Goals
  • Good health and well-being
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