reviewExperimental & Molecular MedicineOct 2, 2023GOLD OA

Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics

YLYeji LeeMJMichaela JeongJPJeongeun ParkHJHyein JungHLHyukjin Lee

Ewha Womans University

PubMed
Indexed incrossrefdoajpubmed

Abstract

Several studies have utilized a lipid nanoparticle delivery system to enhance the effectiveness of mRNA therapeutics and vaccines. However, these nanoparticles are recognized as foreign materials by the body and stimulate innate immunity, which in turn impacts adaptive immunity. Therefore, it is crucial to understand the specific type of innate immune response triggered by lipid nanoparticles. This article provides an overview of the immunological response in the body, explores how lipid nanoparticles activate the innate immune system, and examines the adverse effects and immunogenicity-related development pathways associated with these nanoparticles. Finally, we highlight and explore strategies for regulating…

Citation impact

370
total citations
FWCI
53.74
Percentile
100%
References
147
Citations per year

Authors

5

Topics & keywords

Topics
Keywords
  • Immunogenicity
  • Innate immune system
  • Acquired immune system
  • Immune system
  • Immunity
  • Immunology
  • Medicine
UN Sustainable Development Goals
  • Good health and well-being
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