Transcriptome‐level discovery of survival‐associated biomarkers and therapy targets in non‐small‐cell lung cancer

BACKGROUND AND PURPOSE: Survival rate of patients with lung cancer has increased by over 60% in the recent two decades. With longer survival, the identification of genes associated with survival has emerged as an issue of utmost importance to uncover the most promising biomarkers and therapeutic targets. EXPERIMENTAL APPROACH: An integrated database was set up by combining multiple independent datasets with clinical data and transcriptome-level gene expression measurements. Univariate and multivariate survival analyses were performed to identify genes with higher expression levels linked to shorter survival. The strongest genes were filtered to include only those with known druggability. KEY RESULTS: The…

• NK
  Nemzeti Kutatási és Technológiai Hivatal

  Awards: RRF‐2.3.1‐21‐2022‐00015, TKP2021‐NVA‐15
• AN
  Agence Nationale pour la Gestion des Déchets Radioactifs