Drug-microbiota interactions: an emerging priority for precision medicine
Central South University · National Clinical Research · +4 more institutions
Abstract
Individual variability in drug response (IVDR) can be a major cause of adverse drug reactions (ADRs) and prolonged therapy, resulting in a substantial health and economic burden. Despite extensive research in pharmacogenomics regarding the impact of individual genetic background on pharmacokinetics (PK) and pharmacodynamics (PD), genetic diversity explains only a limited proportion of IVDR. The role of gut microbiota, also known as the second genome, and its metabolites in modulating therapeutic outcomes in human diseases have been highlighted by recent studies. Consequently, the burgeoning field of pharmacomicrobiomics aims to explore the correlation between microbiota variation and IVDR or ADRs. This review…
Citation impact
- FWCI
- 31.67
- Percentile
- 100%
- References
- 543
Authors
5- QZQing ZhaoCorresponding
Central South University, National Clinical Research, Xiangya Hospital Central South University
- YCYao Chen
Central South University, National Clinical Research, Xiangya Hospital Central South University
- WHWeihua Huang
Central South University, National Clinical Research, Xiangya Hospital Central South University
- HZHonghao Zhou
Central South University, National Clinical Research, Xiangya Hospital Central South University
- WZWei Zhang
Central South University, Shantou University, First Affiliated Hospital of Shantou University Medical College, First Affiliated Hospital of Guangdong Pharmaceutical University, Xiangya Hospital Central South University
Topics & keywords
- ADME
- Pharmacogenomics
- Gut flora
- Personalized medicine
- Precision medicine
- Computational biology
- Drug
- Medicine