The IL-17 family in diseases: from bench to bedside
Harbin Medical University · Hainan Medical University
Abstract
The interleukin-17 (IL-17) family comprises six members (IL-17A-17F), and recently, all of its related receptors have been discovered. IL-17 was first discovered approximately 30 years ago. Members of this family have various biological functions, including driving an inflammatory cascade during infections and autoimmune diseases, as well as boosting protective immunity against various pathogens. IL-17 is a highly versatile proinflammatory cytokine necessary for vital processes including host immune defenses, tissue repair, inflammatory disease pathogenesis, and cancer progression. However, how IL-17 performs these functions remains controversial. The multifunctional properties of IL-17 have attracted research…
Citation impact
- FWCI
- 59.78
- Percentile
- 100%
- References
- 345
Authors
4Topics & keywords
- Immunology
- Mechanism (biology)
- Immune system
- Pathogenesis
- Disease
- Proinflammatory cytokine
- Biology
- Signal transduction
- Good health and well-being