Self‐Destructive Copper Carriers Induce Pyroptosis and Cuproptosis for Efficient Tumor Immunotherapy Against Dormant and Recurrent Tumors

Qiao, Luying; Zhu, Guo‐Qing; Jiang, Tengfei; Qian, Yanrong; Sun, Qianqian; Zhao, Guang‐Hui; Gao, Haidong; Li, Chunxia

doi:10.1002/adma.202308241

articleAdvanced MaterialsOct 11, 2023Closed access

Self‐Destructive Copper Carriers Induce Pyroptosis and Cuproptosis for Efficient Tumor Immunotherapy Against Dormant and Recurrent Tumors

LQLuying Qiao GZGuo‐Qing Zhu TJTengfei Jiang YQYanrong Qian QSQianqian Sun

Shandong University · Institut des Sciences Moléculaires · +1 more institution

PubMed

Indexed incrossrefpubmed

Abstract

Activating the strong immune system is a key initiative to counteract dormant tumors and prevent recurrence. Herein, self-destructive and multienzymatically active copper-quinone-GOx nanoparticles (abbreviated as CQG NPs) have been designed to induce harmonious and balanced pyroptosis and cuproptosis using the "Tai Chi mindset" to awaken the immune response for suppressing dormant and recurrent tumors. This cleverly designed material can disrupt the antioxidant defense mechanism of tumor cells by inhibiting the nuclear factor-erythroid 2-related factor 2 (NRF2)-quinone oxidoreductase 1 (NQO1) signaling pathway. Furthermore, combined with its excellent multienzyme activity, it activates NOD-like receptor…

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184

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Topics & keywords

Topics

Keywords

Materials science
Copper
Immunotherapy
Pyroptosis
Cancer research
Nanotechnology
Immunology
Metallurgy

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