Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis

Mitochondrial mass and quality are tightly regulated by two essential and opposing mechanisms, mitochondrial biogenesis (mitobiogenesis) and mitophagy, in response to cellular energy needs and other cellular and environmental cues. Great strides have been made to uncover key regulators of these complex processes. Emerging evidence has shown that there exists a tight coordination between mitophagy and mitobiogenesis, and their defects may cause many human diseases. In this review, we will first summarize the recent advances made in the discovery of molecular regulations of mitobiogenesis and mitophagy and then focus on the mechanism and signaling pathways involved in the simultaneous regulation of…

• NN
  National Natural Science Foundation of China

  Awards: YSBR-075, 32293212, 32230046, 32170780, 92254301
• CA
  Chinese Academy of Sciences

  Award: YSBR-075
• MO
  Ministry of Science and Technology of the People's Republic of China

  Award: 2020YFA0803702
• NU
  Nankai University
• NS
  Natural Science Foundation of Tianjin City

  Award: 20JCYBJC01210