Astrocytes in human central nervous system diseases: a frontier for new therapies
Ikerbasque · University of Manchester · +11 more institutions
Abstract
Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis and defence of the central nervous system (CNS). Astroglia contribute to the pathophysiology of all neurological and neuropsychiatric disorders in ways that can be either beneficial or detrimental to disorder outcome. Pathophysiological changes in astroglia can be primary or secondary and can result in gain or loss of functions. Astroglia respond to external, non-cell autonomous signals associated with any form of CNS pathology by undergoing complex and variable changes in their structure, molecular expression, and function. In addition, internally driven, cell autonomous changes of astroglial innate properties can lead…
Citation impact
- FWCI
- 44.73
- Percentile
- 100%
- References
- 662
Authors
8- AVAlexei VerkhratskyCorresponding
Ikerbasque, University of Manchester, Achucarro Basque Center for Neuroscience, State Research Institute Centre for Innovative Medicine, Chengdu University of Traditional Chinese Medicine, China Medical University
- AMArthur M. Butt
University of Portsmouth
- BLBaoman Li
China Medical University
- PIPéter Illés
Chengdu University of Traditional Chinese Medicine, Leipzig University
- RZRobert Zorec
University of Ljubljana, Celica (Slovenia)
Topics & keywords
- Astrogliosis
- Pathophysiology
- Neuroscience
- Context (archaeology)
- Central nervous system
- Astrocyte
- Biology
- Medicine
- Good health and well-being
Funding
- NNNational Natural Science Foundation of ChinaAwards: 82230127, 82274668, 202003, ZYYCXTD-D-202003
- JAJavna Agencija za Raziskovalno Dejavnost RSAward: P3 310
- RSRussian Science Foundation
- SPSichuan Provincial Administration of Traditional Chinese MedicineAward: 2023zd024
- NINational Institutes of HealthAward: NS084030