Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease
Istituto Pasteur · Sapienza University of Rome · +1 more institution
Abstract
Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms, among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises in various pathways regulating brain functions, and it seems to link different hypotheses and mechanisms of AD neuropathology with high fidelity. The brain is particularly vulnerable to oxidative damage, mainly because of its unique lipid composition, resulting in an amplified cascade of redox reactions that target several cellular components/functions ultimately leading to neurodegeneration. The present review highlights the "OS hypothesis of AD," including amyloid beta-peptide-associated mechanisms, the role of lipid and protein…
Citation impact
- FWCI
- 61.59
- Percentile
- 100%
- References
- 757
Authors
3Topics & keywords
- Neurodegeneration
- Pathogenesis
- Disease
- Oxidative damage
- Oxidative stress
- Alzheimer's disease
- Neuroscience
- Oxidative phosphorylation