Quantifying the Expanding Landscape of Clinical Actionability for Patients with Cancer

There is a continuing debate about the proportion of cancer patients that benefit from precision oncology, attributable in part to conflicting views as to which molecular alterations are clinically actionable. To quantify the expansion of clinical actionability since 2017, we annotated 47,271 solid tumors sequenced with the MSK-IMPACT clinical assay using two temporally distinct versions of the OncoKB knowledge base deployed 5 years apart. Between 2017 and 2022, we observed an increase from 8.9% to 31.6% in the fraction of tumors harboring a standard care (level 1 or 2) predictive biomarker of therapy response and an almost halving of tumors carrying nonactionable drivers (44.2% to 22.8%). In tumors with…

• PC
  Prostate Cancer Foundation

  Award: P30 CA008748
• MS
  Memorial Sloan-Kettering Cancer Center

  Award: CA008748
• NI
  National Institutes of Health

  Award: P30 CA008748
• MA
  Marie-Josée and Henry R. Kravis Center for Molecular Oncology

  Award: P30 CA008748