Microbiota from Alzheimer’s patients induce deficits in cognition and hippocampal neurogenesis
University College Cork · APC Microbiome Institute · +5 more institutions
Abstract
Alzheimer's disease is a complex neurodegenerative disorder leading to a decline in cognitive function and mental health. Recent research has positioned the gut microbiota as an important susceptibility factor in Alzheimer's disease by showing specific alterations in the gut microbiome composition of Alzheimer's patients and in rodent models. However, it is unknown whether gut microbiota alterations are causal in the manifestation of Alzheimer's symptoms. To understand the involvement of Alzheimer's patient gut microbiota in host physiology and behaviour, we transplanted faecal microbiota from Alzheimer's patients and age-matched healthy controls into microbiota-depleted young adult rats. We found impairments…
Citation impact
- FWCI
- 19.69
- Percentile
- 100%
- References
- 130
Authors
19- SGStefanie GrabruckerCorresponding
University College Cork, APC Microbiome Institute
- MMMoira Marizzoni
Centro San Giovanni di Dio Fatebenefratelli, Istituti di Ricovero e Cura a Carattere Scientifico
- ESEdina Silajdžić
King's College London
- NLNicola Lopizzo
University of Milan, Centro San Giovanni di Dio Fatebenefratelli, Istituti di Ricovero e Cura a Carattere Scientifico
- EMElisa Mombelli
Centro San Giovanni di Dio Fatebenefratelli, Istituti di Ricovero e Cura a Carattere Scientifico
Topics & keywords
- Neurogenesis
- Hippocampal formation
- Neuroscience
- Cognition
- Psychology
- Hippocampus
- Dementia
- Cognitive reserve
- Good health and well-being