reviewMacromoleculesOct 18, 2023HYBRID OA

Stimuli-Responsive Hydrogels: The Dynamic Smart Biomaterials of Tomorrow

Utrecht University

PubMed
Indexed incrossrefpubmed

Abstract

In the past decade, stimuli-responsive hydrogels are increasingly studied as biomaterials for tissue engineering and regenerative medicine purposes. Smart hydrogels can not only replicate the physicochemical properties of the extracellular matrix but also mimic dynamic processes that are crucial for the regulation of cell behavior. Dynamic changes can be influenced by the hydrogel itself (isotropic vs anisotropic) or guided by applying localized triggers. The resulting swelling-shrinking, shape-morphing, as well as patterns have been shown to influence cell function in a spatiotemporally controlled manner. Furthermore, the use of stimuli-responsive hydrogels as bioinks in 4D bioprinting is very promising as…

Citation impact

177
total citations
FWCI
18.43
Percentile
100%
References
142
Citations per year

Authors

7

Topics & keywords

Keywords
  • Self-healing hydrogels
  • Biofabrication
  • Tissue engineering
  • Nanotechnology
  • Regenerative medicine
  • Smart material
  • Materials science
  • Extracellular matrix
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