Pegcetacoplan for the treatment of geographic atrophy secondary to age-related macular degeneration (OAKS and DERBY): two multicentre, randomised, double-masked, sham-controlled, phase 3 trials

Heier, Jeffrey S.; Lad, Eleonora M.; Holz, Frank G.; Rosenfeld, Philip J.; Guymer, Robyn H.; Boyer, David S.; Grossi, F; Baumal, Caroline R.; Korobelnik, Jean‐François; Slakter, Jason S.; Waheed, Nadia K.; Metlapally, Ravi; Pearce, Ian; Steinle, Nathan; Francone, A; Hu, Allen; Lally, David R.; Deschatelets, Pascal; Francois, Cedric; Bliss, Caleb; Staurenghi, Giovanni; Monés, Jordi; Singh, Rishi P.; Ribeiro, Ramiro; Wykoff, Charles C.; Cole, Abosede O; Gerstenblith, Adam T.; Kotagiri, Ajay; Edwards, Albert O.; Zambrano, Alberto D; Eaton, Alexander M.; Rubowitz, Alexander; Lyon, Alice T.; Chiang, Allen; Ho, Allen C.; Hu, Allen; Guerami, Amir; Dessouki, Amr; Carvalho, André Corrêa Maia de; Emanuelli, Andrés; Chang, Andrew; Antoszyk, Andrew N.; Francone, A; Prasad, Anita; Wolf, Armin; Khanani, Arshad M.; Abbey, Ashkan M.; Moulana, Asma; Wihelm, Barbara; Sikorski, Bartosz L.; Kuppermann, Baruch D.; Wolff, Benjamin; Jewart, Brian; Brian, K.; Chan-Kai, Brian T.; Mein, Calvin E.; Hoyng, Carel B.; Awh, Carl C.; Regillio, Carl; Zeolite, Carlos; Baumal, Caroline R.; Creuzot‐Garcher, Catherine; Maury, Catherine Français; Wykoff, Charles C.; Newell, Charles K; Jhaveri, Chirag; Lohmann, Chris P.; Dinah, Christiana; Ma, Colin; Crawford, Courtney; Parke, D Wilkin; Lavinsky, Daniel; Roth, Daniel B.; Pieramici, Dante J.; Moshfeghi, Darius M.; Levin, Darrin; Saperstein, David A.; Brown, David M.; Gaucher, David; Lally, David R.; Liao, David; Brown, David Warren; Goldstein, Debra A.; Marcus, Dennis M.; Chan, Derek G.; Dhoot, Dilsher S.; Tacite, Domingo; Zalewski, Dominik; Espana, Edgar M.; Lad, Eleonora M.; Souied, Eric H.; Suan, Eric; Eting, Eva; Sola, Federico Furno; Bats, F. De; Bandello, Francesco; Gómez‐Ulla, Francisco; Devin, François; Holz, Frank G.; Chen, Fred K.; Makkouk, Fuad; Dyer, Gawain; Spital, George; Staurenghi, Giovanni; Stoller, Glenn; Cousins, Gwen; Salehi-Had, Hani; Agostini, Hansjürgen; Eleftheriadis, Haralabos; Weiss, Harold B.; Sultan, Harris; Massé, Hélène; Pearce, Ian; Dias, Indra; Barbazetto, Irene; Rosenblatt, Irit; Suñer, Iván J.; Kovach, Jaclyn L.; Kałuzný, J; Borthwick, James; Howard, J. G.; Wong, James; Ernest, Jan; Němčanský, Jan; Ysasaga, J. Edward; Handza, Jason M.; Moreno, Javier Antonio Montero; Korobelnik, Jean‐François; Heier, Jeffrey S.; Arnold, Jennifer; Brown, Jeremiah; Bafalluy, Joaquín; Pearlman, Joel; Pitcher, John D.; Kitchens, John W.; Carlson, John; Gilhotra, Jolly; Fein, Jordana; Monés, Jordi; Luna, José D.; Ruiz‐Moreno, José M.; Coney, Joseph; Sallum, Juliana Maria Ferraz; Olsen, Karl R.; Blobner, Katharina; Macoul, Katherine A; Oh, Kean T.; Malik, Khurram; Hattenbach, Lars‐Olof; Kodjikian, Laurent; Neto, Laurentino Biccas; Singerman, Lawrence J.; Altay, Lebriz; Sheck, Leo-H; Feiner, Leonard; Harris, Lindsey D; Chishold, Lionel D; Rao, Llewelyn; Nehemy, Márcio Bittar; Elizalde, M. J. Capella; Gamulescu, Maria‐Andreea; Saravia, Mario; Johnson, Mark W.; McKibbin, Martin; MacCumber, Mathew W.; Vidosevich, Matko; Ohr, Matthew; Samuel, Michael; Singer, Michael; Cassell, Michael; Dollin, Michael; Elman, Michael J.; Ip, Michael S.; Goldstein, Michaella; Busquets, Miguel; Mititelu, Mihai; Shah, Milan; Veith, Miroslav; Fineman, Mitchell S.; Varano, Monica; Christmas, Nancy; Steinle, Nathan; Chaudhry, Nauman; Chinskey, Nicholas D.; Eter, Nicole; London, Nikolas; Mathalone, Nurit; Schlottmann, Patricio G.; Coady, Patrick A.; Higgins, Patrick M; Raskauskas, Paul; Yates, Paul; Bernstein, Paul S.; Mitchell, Paul; Monsour, Paul D.; Raphaelian, Paul; Stanga, Paulo; Stodůlka, Pavel; Issa, Peter Charbel; Pavan, Peter R.; Ferrone, Phil J; Oleksy, Piotr; Abraham, Prema; Mruthyunjaya, Prithvi; Nguyen, Quan Dong; Reddy, Rahul K.; Khurana, Rahul N.; Tuli, Raman; Tadayoni, Ramin; Katz, Randy; Arora, Rashi; Schlingemann, Reinier O.; Rosen, Richard B.; Gale, Richard; Scartozzi, Richard; Isernharge, Ricky; Singh, Rishi P.; Stoltz, Robert A.; Avery, Robert L.; Wirthlin, Robert S.; Guymer, Robyn H.; Goldberg, Roger A.; Frenkel, R. E. P.; Belfort, Rubens Jr; Mohand‐Saïd, Saddek; Grisanti, Salvatore; Razavi, Sam; Fraser‐Bell, Samantha; Shah, Sandeep N.; Wickremasinghe, Sanjeewa; Haug, Sara J.; Adrean, Sean D.; Priglinger, Siegfried; Esposti, Simona Degli; Guest, Stephen; Huddleston, Stephen; Itty, Sujit; Moon, Suk J.; Bhatia, Sumit P.; Gupta, Sunil; Patel, Sunil; Garg, Sunir J.; Joshi, Sunir; Nghiem‐Buffet, Sylvia; Johnson, T. Mark; Jaouni, Tareq; Ach, Thomas; Williams, Thomas R.; Sheidow, Tom; Cleland, Timothy P.; You, Timothy; Pető, Tünde; Konidaris, Vasileios; González, Víctor H.; Korda, Vladimír; Freeman, William R.; Bridges, William; Barak, Yoreh; Zagórski, Z; Yehoshua, Zohar; Dubská, Z

doi:10.1016/s0140-6736(23)01520-9

articleThe LancetOct 1, 2023GREEN OA

Pegcetacoplan for the treatment of geographic atrophy secondary to age-related macular degeneration (OAKS and DERBY): two multicentre, randomised, double-masked, sham-controlled, phase 3 trials

JSJeffrey S. Heier EMEleonora M. Lad FGFrank G. Holz PJPhilip J. Rosenfeld RHRobyn H. Guymer

Ophthalmic Consultants of Boston · Duke Medical Center · +20 more institutions

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Topics & keywords

Topics

Keywords

Medicine
Macular degeneration
Population
Geographic atrophy
Clinical endpoint
Clinical trial
Atrophy
Ophthalmology

UN Sustainable Development Goals

Quality Education

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Funding

AP
Apellis Pharmaceuticals