Injectable Antiswelling and High-Strength Bioactive Hydrogels with a Wet Adhesion and Rapid Gelling Process to Promote Sutureless Wound Closure and Scar-free Repair of Infectious Wounds

Developing injectable antiswelling and high-strength bioactive hydrogels with wet tissue adhesiveness and a rapid gelling process to meet the requirements for rapid hemostasis, sutureless wound closure, and scar-free repair of infected skin wounds continues to have ongoing challenges. Herein, injectable, antibacterial, and antioxidant hydrogel adhesives based on poly(citric acid-co-polyethylene glycol)-g-dopamine and amino-terminated Pluronic F127 (APF) micelles loaded with astragaloside IV (AS) are prepared. The H2O2/horseradish peroxidase (HRP) system is used to cause cross-linking of the hydrogel network through oxidative coupling between catechol groups and chemical cross-linking between the catechol group…

• NN
  National Natural Science Foundation of China

  Awards: 51971171, 52003216, 82272155, 52273149
• CP
  China Postdoctoral Science Foundation

  Awards: 2020T130501, 2019M653612
• NS
  Natural Science Foundation of Shaanxi Province

  Award: 2020JQ-057
• SU
  Shaanxi University of Science and Technology

  Award: 20200404
• KR
  Key Research and Development Projects of Shaanxi Province

  Award: 2023-YBSF-150