Cyclic Peptides for Drug Development
École Polytechnique Fédérale de Lausanne
Abstract
Cyclic peptides are fascinating molecules abundantly found in nature and exploited as molecular format for drug development as well as other applications, ranging from research tools to food additives. Advances in peptide technologies made over many years through improved methods for synthesis and drug development have resulted in a steady stream of new drugs, with an average of around one cyclic peptide drug approved per year. Powerful technologies for screening random peptide libraries, and de novo generating ligands, have enabled the development of cyclic peptide drugs independent of naturally derived molecules and now offer virtually unlimited development opportunities. In this review, we feature…
Citation impact
- FWCI
- 50.12
- Percentile
- 100%
- References
- 97
Authors
3Topics & keywords
- Cyclic peptide
- Drug development
- Peptide
- Drug
- Drug discovery
- Computational biology
- Small molecule
- Chemistry