Matrix effects demystified: Strategies for resolving challenges in analytical separations of complex samples
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Abstract
Matrix effects can significantly impede the accuracy, sensitivity, and reliability of separation techniques presenting a formidable challenge to the analytical process. It is crucial to address matrix effects to achieve accurate and precise measurements in complex matrices. The multifaceted nature of matrix effects which can be influenced by factors such as target analyte, sample preparation protocol, composition, and choice of instrument necessitates a pragmatic approach when analyzing complex matrices. This review aims to highlight common challenges associated with matrix effects throughout the entire analytical process with emphasis on gas chromatography-mass spectrometry, liquid chromatography-mass…
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186
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Authors
5Topics & keywords
Topics
Keywords
- Matrix (chemical analysis)
- Analyte
- Ion suppression in liquid chromatography–mass spectrometry
- Sample preparation
- Mass spectrometry
- Computer science
- Process (computing)
- Chemistry
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