CD8 T-cell subsets: heterogeneity, functions, and therapeutic potential

CD8 T cells play crucial roles in immune surveillance and defense against infections and cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and acquire effector functions, enabling them to eliminate infected or malignant cells. Traditionally, cytotoxic T cells, characterized by their ability to produce effector cytokines and release cytotoxic granules to directly kill target cells, have been recognized as the constituents of the predominant effector T-cell subset. However, emerging evidence suggests distinct subsets of effector CD8 T cells that each exhibit unique effector functions and therapeutic potential. This review highlights recent advancements in our understanding of CD8…

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  National Research Foundation
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  National Research Foundation of Korea

  Awards: 2022R1C1C201061212, 2020R1A3B207889011, 2022R1A6A1A03046247