Nanosensitizer-mediated augmentation of sonodynamic therapy efficacy and antitumor immunity
Brigham and Women's Hospital · Harvard University · +5 more institutions
Abstract
Abstract The dense stroma of desmoplastic tumor limits nanotherapeutic penetration and hampers the antitumor immune response. Here, we report a denaturation-and-penetration strategy and the use of tin monosulfide nanoparticles (SnSNPs) as nano-sonosensitizers that can overcome the stromal barrier for the management of desmoplastic triple-negative breast cancer (TNBC). SnSNPs possess a narrow bandgap (1.18 eV), allowing for efficient electron (e − )-hole (h + ) pair separation to generate reactive oxygen species under US activation. More importantly, SnSNPs display mild photothermal properties that can in situ denature tumor collagen and facilitate deep penetration into the tumor mass upon near-infrared…
Citation impact
- FWCI
- 22.46
- Percentile
- 100%
- References
- 67
Authors
14- YLYongjiang LiCorresponding
Brigham and Women's Hospital, Harvard University
- WCWei Chen
Brigham and Women's Hospital, Harvard University
- YKYong Kang
Tianjin University, Tianjin Medical University
- XZXueyan Zhen
Brigham and Women's Hospital, Harvard University
- ZZZhuoming Zhou
Brigham and Women's Hospital, Harvard University
Topics & keywords
- Sonodynamic therapy
- Photothermal therapy
- Nanomedicine
- Cancer research
- Photodynamic therapy
- Stroma
- Radiation therapy
- Immunotherapy