Epigenetic regulation during cancer transitions across 11 tumour types

. Although the genetic contributions to oncogenic transitions have been investigated, epigenetic drivers remain less understood. Here we constructed a pan-cancer epigenetic and transcriptomic atlas using single-nucleus chromatin accessibility data (using single-nucleus assay for transposase-accessible chromatin) from 225 samples and matched single-cell or single-nucleus RNA-sequencing expression data from 206 samples. With over 1 million cells from each platform analysed through the enrichment of accessible chromatin regions, transcription factor motifs and regulons, we identified epigenetic drivers associated with cancer transitions. Some epigenetic drivers appeared in multiple cancers (for example,…

• AJ
  Alvin J. Siteman Cancer Center
• NH
  National Human Genome Research Institute

  Awards: R01HG009711, HG000045, T32 HG000045
• NC
  National Cancer Institute

  Awards: U24CA248453, U24CA210972, U2CCA233303, R01CA260112, R01HG009711