Astrocyte morphology
University of North Carolina at Chapel Hill · University of North Carolina Health Care · +3 more institutions
Abstract
Astrocytes are predominant glial cells that tile the central nervous system (CNS). A cardinal feature of astrocytes is their complex and visually enchanting morphology, referred to as bushy, spongy, and star-like. A central precept of this review is that such complex morphological shapes evolved to allow astrocytes to contact and signal with diverse cells at a range of distances in order to sample, regulate, and contribute to the extracellular milieu, and thus participate widely in cell-cell signaling during physiology and disease. The recent use of improved imaging methods and cell-specific molecular evaluations has revealed new information on the structural organization and molecular underpinnings of…
Citation impact
- FWCI
- 28.04
- Percentile
- 100%
- References
- 122
Authors
3Topics & keywords
- Biology
- Astrocyte
- Neuroscience
- Multicellular organism
- Morphogenesis
- Cell type
- Cytoarchitecture
- Morphology (biology)
- Zero hunger
Funding
- ISIowa Science Foundation
- RFRessler Family Foundation
- IDInternational Development Research Centre
- ISIsrael Science Foundation
- AFAzrieli Foundation
- FDFondation de l'Hôpital Général de MontréalAwards: R35 NS111583, R01DA047444, R01AG075955
- NINational Institutes of HealthAwards: NS111583, R35 NS111583, DP2 NS136873-01
- CICanadian Institutes of Health ResearchAwards: PJT148569, 156247, PJT180573
- NSNatural Sciences and Engineering Research Council of CanadaAwards: 69404, 408044-2011