Size-Dependent In Vivo Transport of Nanoparticles: Implications for Delivery, Targeting, and Clearance
South China University of Technology
Abstract
Understanding the in vivo transport of nanoparticles provides guidelines for designing nanomedicines with higher efficacy and fewer side effects. Among many factors, the size of nanoparticles plays a key role in controlling their in vivo transport behaviors due to the existence of various physiological size thresholds within the body and size-dependent nano-bio interactions. Encouraged by the evolving discoveries of nanoparticle-size-dependent biological effects, we believe that it is necessary to systematically summarize the size-scaling laws of nanoparticle transport in vivo. In this review, we summarized the size effect of nanoparticles on their in vivo transport along their journey in the body: begin with…
Citation impact
- FWCI
- 49.60
- Percentile
- 100%
- References
- 250
Authors
6Topics & keywords
- In vivo
- Nanoparticle
- Nanomedicine
- Nanotechnology
- Materials science
- Biology