The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods

ChEMBL (https://www.ebi.ac.uk/chembl/) is a manually curated, high-quality, large-scale, open, FAIR and Global Core Biodata Resource of bioactive molecules with drug-like properties, previously described in the 2012, 2014, 2017 and 2019 Nucleic Acids Research Database Issues. Since its introduction in 2009, ChEMBL's content has changed dramatically in size and diversity of data types. Through incorporation of multiple new datasets from depositors since the 2019 update, ChEMBL now contains slightly more bioactivity data from deposited data vs data extracted from literature. In collaboration with the EUbOPEN consortium, chemical probe data is now regularly deposited into ChEMBL. Release 27 made curated data…

• UO
  University of Miami
• UO
  University of New Mexico
• WT
  Wellcome Trust

  Awards: 218244/Z/19/Z, 104104/A/14/Z
• EB
  European Bioinformatics Institute
• NI
  National Institutes of Health

  Awards: U24 224370, U54 CA189205