Smart‐Responsive Multifunctional Therapeutic System for Improved Regenerative Microenvironment and Accelerated Bone Regeneration via Mild Photothermal Therapy

Abstract The treatment of bone defects remains a substantial clinical challenge due to the lack of spatiotemporal management of the immune microenvironment, revascularization, and osteogenic differentiation. Herein, deferoxamine (DFO)‐loaded black phosphorus nanosheets decorated by polydopamine layer are prepared (BPPD) and compounded into gelatin methacrylate/sodium alginate methacrylate (GA) hybrid hydrogel as a smart‐responsive therapeutic system (GA/BPPD) for accelerated bone regeneration. The BPPD nanocomposites served as bioactive components and near‐infrared (NIR) photothermal agents, which conferred the hydrogel with excellent NIR/pH dual‐responsive properties, realizing the stimuli‐responsive release…

• NN
  National Natural Science Foundation of China

  Award: 82302392
• MO
  Ministry of Science and Technology of the People's Republic of China
• CP
  China Postdoctoral Science Foundation

  Award: 2023M732711
• WU
  Wuhan University
• ZH
  Zhongnan Hospital of Wuhan University

  Award: ZNLH202202
• NF
  Northwest Fisheries Science Center