reviewEuropean Heart JournalNov 3, 2023HYBRID OA

Mendelian randomization for cardiovascular diseases: principles and applications

SCSusanna C. LarssonASAdam S. ButterworthSBStephen Burgess

Uppsala University · Karolinska Institutet · +7 more institutions

PubMed
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Abstract

Large-scale genome-wide association studies conducted over the last decade have uncovered numerous genetic variants associated with cardiometabolic traits and risk factors. These discoveries have enabled the Mendelian randomization (MR) design, which uses genetic variation as a natural experiment to improve causal inferences from observational data. By analogy with the random assignment of treatment in randomized controlled trials, the random segregation of genetic alleles when DNA is transmitted from parents to offspring at gamete formation is expected to reduce confounding in genetic associations. Mendelian randomization analyses make a set of assumptions that must hold for valid results. Provided that the…

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Topics & keywords

Topics
Keywords
  • Mendelian randomization
  • Medicine
  • Confounding
  • Observational study
  • Causal inference
  • Mendelian inheritance
  • Genome-wide association study
  • Bioinformatics
UN Sustainable Development Goals
  • Good health and well-being
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