articleNature MedicineNov 9, 2023HYBRID OA

Risk of hematological malignancies from CT radiation exposure in children, adolescents and young adults

MBMagda Bosch de Basea GómezITIsabelle Thierry-ChefRHRichard HarbronMHMichael HauptmannGBGraham Byrnes

Universitat Pompeu Fabra · Instituto de Salud Carlos III · +25 more institutions

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Abstract

Over one million European children undergo computed tomography (CT) scans annually. Although moderate- to high-dose ionizing radiation exposure is an established risk factor for hematological malignancies, risks at CT examination dose levels remain uncertain. Here we followed up a multinational cohort (EPI-CT) of 948,174 individuals who underwent CT examinations before age 22 years in nine European countries. Radiation doses to the active bone marrow were estimated on the basis of body part scanned, patient characteristics, time period and inferred CT technical parameters. We found an association between cumulative dose and risk of all hematological malignancies, with an excess relative risk of 1.96 (95%…

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Topics & keywords

Topics
Keywords
  • Medicine
  • Radiation exposure
  • Pediatrics
  • Young adult
  • Oncology
  • Internal medicine
  • Nuclear medicine
UN Sustainable Development Goals
  • Good health and well-being
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