reviewJournal of Agricultural and Food ChemistryNov 10, 2023HYBRID OA

The Chemistry Behind the Folin–Ciocalteu Method for the Estimation of (Poly)phenol Content in Food: Total Phenolic Intake in a Mediterranean Dietary Pattern

MPMaria PérezIDInés Domínguez‐LópezRMRosa M. Lamuela‐Raventós

Instituto de Salud Carlos III · Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition · +1 more institution

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Abstract

The Folin-Ciocalteu assay is a reference method for the quantification of total (poly)phenols in food. This review explains the fundamental mechanism of the redox reaction on which the method is based and looks at some of the practical considerations concerning its application. To accurately estimate the antioxidant capacity of (poly)phenolic compounds, a thorough knowledge of their structural characteristics is essential, as the two are closely associated. Therefore, to help researchers interpret the results of the Folin-Ciocalteu method, this review also summarizes some of the main phenolic structural features. Finally, we have used the Folin-Ciocalteu method to estimate the total phenolic intake associated…

Citation impact

341
total citations
FWCI
34.83
Percentile
100%
References
55
Citations per year

Authors

3

Topics & keywords

Topics
Keywords
  • Phenol
  • Phenols
  • Chemistry
  • Olive oil
  • Mediterranean diet
  • Food science
  • Wine
  • Vegetable oil
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