Bioinspired porous three-coordinated single-atom Fe nanozyme with oxidase-like activity for tumor visual identification via glutathione
Northwestern Polytechnical University · Ministry of Industry and Information Technology · +3 more institutions
Abstract
Abstract Inspired by structures of natural metalloenzymes, a biomimetic synthetic strategy is developed for scalable synthesis of porous Fe-N 3 single atom nanozymes (pFeSAN) using hemoglobin as Fe-source and template. pFeSAN delivers 3.3- and 8791-fold higher oxidase-like activity than Fe-N 4 and Fe 3 O 4 nanozymes. The high catalytic performance is attributed to (1) the suppressed aggregation of atomically dispersed Fe; (2) facilitated mass transfer and maximized exposure of active sites for the created mesopores by thermal removal of hemoglobin (2 ~ 3 nm); and (3) unique electronic configuration of Fe-N 3 for the oxygen-to-water oxidation pathway (analogy with natural cytochrome c oxidase). The pFeSAN is…
Citation impact
- FWCI
- 17.52
- Percentile
- 100%
- References
- 67
Authors
11- DCDa ChenCorresponding
Northwestern Polytechnical University, Ministry of Industry and Information Technology
- ZXZhaoming Xia
Southern University of Science and Technology
- GZGuo Zhixiong
Northwestern Polytechnical University, Ministry of Industry and Information Technology
- WGWangyan Gou
Northwestern Polytechnical University, Ministry of Industry and Information Technology
- JZJunlong Zhao
Air Force Medical University
Topics & keywords
- Glutathione
- Catalysis
- Detection limit
- Chemistry
- Porosity
- Electrochemistry
- Combinatorial chemistry
- Materials science