Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets

Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects the survival of aerobic species and plays a prominent role in cardiovascular diseases. From the research history and milestone events related to hypoxia in cardiovascular development and diseases, The "hypoxia-inducible factors (HIFs) switch" can be observed from both temporal and spatial perspectives, encompassing the occurrence and progression of hypoxia (gradual decline in oxygen concentration), the acute and chronic manifestations of hypoxia, and the geographical characteristics of hypoxia (natural selection at high altitudes). Furthermore, hypoxia signaling pathways are associated with natural rhythms, such as…

• NN
  National Natural Science Foundation of China

  Awards: T2288101, 19MC1910300, 82370261, 82200290
• CP
  China Postdoctoral Science Foundation

  Awards: 2022M710776, T2288101
• GS
  Guizhou Science and Technology Department
• CA
  Chinese Academy of Medical Sciences

  Award: 2019-I2M-5-060
• SC
  Shanghai Clinical Research Center

  Award: 19MC1910300
• NP
  National Postdoctoral Program for Innovative Talents

  Award: BX20220094