γδ T cells: origin and fate, subsets, diseases and immunotherapy

Abstract The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and hyperactivation, highlights the potential of immune renormalization as a promising strategy in disease treatment. In recent years, our primary focus has centered on γδ T cell-based immunotherapy, particularly pioneering the use of allogeneic Vδ2 + γδ T cells for treating late-stage solid tumors and tuberculosis patients. However, we recognize untapped potential and optimization opportunities to fully harness γδ T cell effector functions in immunotherapy. This review aims to thoroughly examine γδ T cell immunology and its role in diseases. Initially, we elucidate functional differences between γδ T cells and…

• DF
  Deutsche Forschungsgemeinschaft

  Award: Ka 502/19
• NN
  National Natural Science Foundation of China

  Awards: 81920108027, 32270950, 82002787, 32030036