reviewImmunity & AgeingNov 24, 2023GOLD OA

Toll-like receptor 4 (TLR4): new insight immune and aging

HKHyojin KimHKHyemin KimJLJeong‐Hyung LeeCHCheol Hwangbo

Gyeongsang National University · Kangwon National University

PubMed
Indexed incrossrefdoajpubmed

Abstract

TLR4, a transmembrane receptor, plays a central role in the innate immune response. TLR4 not only engages with exogenous ligands at the cellular membrane's surface but also interacts with intracellular ligands, initiating intricate intracellular signaling cascades. Through MyD88, an adaptor protein, TLR4 activates transcription factors NF-κB and AP-1, thereby facilitating the upregulation of pro-inflammatory cytokines. Another adapter protein linked to TLR4, known as TRIF, autonomously propagates signaling pathways, resulting in heightened interferon expression. Recently, TLR4 has garnered attention as a significant factor in the regulation of symptoms in aging-related disorders. The persistent inflammatory…

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366
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56.83
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100%
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Authors

4

Topics & keywords

Topics
Keywords
  • TLR4
  • TRIF
  • Toll-like receptor
  • Signal transduction
  • Innate immune system
  • Cell biology
  • Signal transducing adaptor protein
  • Immune system
UN Sustainable Development Goals
  • Good health and well-being
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