reviewJournal of NeuroinflammationNov 27, 2023GOLD OA

Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis

AWAnbiao WuJZJiyan Zhang

Beijing Institute of Education · Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences · +1 more institution

PubMed
Indexed incrossrefdoajpubmed

Abstract

As one of most common and severe mental disorders, major depressive disorder (MDD) significantly increases the risks of premature death and other medical conditions for patients. Neuroinflammation is the abnormal immune response in the brain, and its correlation with MDD is receiving increasing attention. Neuroinflammation has been reported to be involved in MDD through distinct neurobiological mechanisms, among which the dysregulation of neurogenesis in the dentate gyrus (DG) of the hippocampus (HPC) is receiving increasing attention. The DG of the hippocampus is one of two niches for neurogenesis in the adult mammalian brain, and neurotrophic factors are fundamental regulators of this neurogenesis process.…

Citation impact

262
total citations
FWCI
30.36
Percentile
100%
References
276
Citations per year

Authors

2

Topics & keywords

Topics
Keywords
  • Neuroinflammation
  • Neurogenesis
  • Dentate gyrus
  • Neuroscience
  • Hippocampus
  • Hippocampal formation
  • Microglia
  • Psychology
UN Sustainable Development Goals
  • Good health and well-being
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